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Comparison of RNAseq datasets To enable a meaningful comparison of datasets, we use a customized ranking factor (RF), defined as: This approach combines both the magnitude of gene expression change (log 2 fold change) and the statistical significance (adjusted P -value) into a single metric, providing a more robust measure of gene importance

[118] The S -(+) and R -() stereoisomers of ketamine bind to the dizocilpine site of the NMDA receptor with different affinities, the former showing approximately 3- to 4-fold greater affinity for the receptor than the latter

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