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It has been proposed that the PI Z variant may aggregate into polymers that precipitate and accumulate in cutaneous soft tissues, leading to inflammation and necrotizing skin lesions ( A1AT is the most abundant serum serine protease inhibitor with anti-protease property ( Figure 1 ) ( Figure 1 Data on the safety of A1AT replacement therapy remain limited due to the rarity of the underlying condition, which currently has only one approved indication for treatment

This mechanism is the focus of most current research interest, particularly in studies on stubborn visceral fat and metabolic regulation

Many neuropeptides co-exist in the same neurons, where they influence production and secretion of one another, thus exerting a neuromodulatory role [21, 23, 37]

one or more amino acid substitutions can be made that result in elimination of one or more variable region framework glycosylation sites to thereby eliminate glycosylation at that site

Glutathione disulfide (GSSG) as a marker of oxidative injury to brain mitochondria