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In 2023, the American Cancer Society estimated that there will be approximately 1.96 million new cancer cases and 6,09,820 cancer-related deaths in the United States alone (Siegel et al., 2023)

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NADPH, HCA, and Kyn had the greatest PLS-DA VIP (Fig

An additional, longer density on the periphery of the monomer within the trimer could not be identified, but was thought to arise from secondary transmembrane structure as well, due to the mostly hydrophobic nature of the protein (Morgenstern et al ., 1985)

HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells