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Specifically, single-target drugs are often limited by insufficient efficacy, rapid development of resistance, and significant side effects (Han Li and Chen, 2015

Under conditions of reduced oxygenation, cells with high glycolytic activity that produce significant amounts of lactate release it into the interstitium through the MCT4 transporter

Molecular Structure AHK-CU consists of alanine, histidine, and lysine bound to copper

Aliquots of 2 mL cell suspension were treated with either ddH 2 O (no chlorination), a 1/1 molar ratio of HOCl/PE (320 M HOCl), or a 10-fold molar excess of HOCl/PE (3.2 mM HOCl) for 10 min at 37 C

33 Oxidative stress is associated with the pathophysiology of cardiovascular diseases (CVDs), while antioxidants are involved in neutralizing ROS and protecting against oxidative stress