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* Correspondence: Lidan Yang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Research indicates that cigarette smokers, diabetics, alcohol drinkers, and individuals with digestive problems are also prone to being B12 deficient

Research has examined its effects on nitric oxide synthase activity, growth factor receptor expression, collagen deposition in connective tissue models, and intestinal epithelial cell protection

Sessions are typically performed weekly during an initial treatment phase

Betaine is a source of up to 60% of the methyl (CH 3 ) groups required for the methylation of homocysteine (10)