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Sample collection On day 14, mice were humanely euthanized using carbon dioxide (CO 2 ) inhalation followed by cervical dislocation to ensure death, after which dissections were performed

Cellular oxidative metabolism produces free radicals and organic peroxides as by-products during cellular mitochondrial electron transport or through metal-catalyzed oxidation of metabolites and oxidoreductases ( Moreover, nitric oxide is produced in hypoxic conditions in a respiratory chain reaction, and RNS may trigger reactive species production, such as reactive aldehydes, malondialdehyde (MDA) and 4-hydroxy-2-non-enal (Lamy et al., 1996

Under normal circumstances this dissociation is triggered by cAMP

Enthusiasm toward emerging therapies is tempered by a realization that current research focuses heavily on induction agents

DILI can also present with acute liver failure
