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doi: 10.1371/journal.pone.0187515

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Yes, this is how Im experiencing the side-effects (mainly headaches and nausea) as well they undulate (come in waves) up and down and up and down

Therefore, a two-pulse delivery system was recently reported which could facilitate adjuvant(s) release prior to the drug release and reduce susceptibility to enzymatic degradation and/or improve mucosal permeation (Del Curto et al., 2011)

In addition, much remains to be learned about the sequence of structural remodeling that occurs at the contact site between the axonal bouton and the spine, and how such sequence associates with formation and elimination of synapses