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The peaks represent maximum concentration (Cmax) shortly after dosing, while the troughs represent minimum concentration (Cmin) just before the next dose

Yan Y, Nguyen K, K-A D, Ueno N, Andreeff M , Battula VL

Marashly ET & Bohlega SA

doi: 10.3389/fphys.2025.1700313 Received 06 September 2025 Revised 21 October 2025 Accepted 22 October 2025 Published 12 November 2025 Corrected 09 January 2026 Volume 16 - 2025 Edited by Kanhaiya Singh, University of Pittsburgh, United States Reviewed by Roxana Carb, Instituto Nacional de Cardiologa Ignacio Chvez, Mexico Pongpan Tanajak, Rehabilitation Center, Thailand Updates Copyright 2025 Tan, Guo, Zhou and Yuan

doi: 10.1038/srep45521