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doi: 10.3390/socsci11010026

This elegant therapeutic approach sees its efficacy, however, crippled by several factors: (i) the number of nanoparticles that accumulate in the tumor is usually low due to a reduced targeting efficiency 5 , (ii) the properties of the tumor microenvironment limit the generation of ROS, and (iii) the optical properties of the tissues drastically reduce the amount of light that can reach the NPs housed intratumorally 6

Reader beware, this is a complex topic, but nonetheless, lets dig into this a bit more, with a look at how MTHFR relates to DNA methylation and the one-carbon pathway

The rG4 structure is disrupted in the presence of Mg 2+ , as indicated by a lower 265 nm peak ( Fig

10.1038/nature23876 Nature 2 AlexandrescuD