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As some deficiencies (particularly vitamin B 12 ) may take years to present clinical symptoms, the long-term management of vitamin B deficiency is crucial

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Competing interests: The BMJ has judged that there are no disqualifying financial ties to commercial companies

Functionally related genes are frequently located near each other in the genome of prokaryotes (Jacob and Monod, 1961)

Cyanocobalamin is the FDA-approved standard for treating deficiency and is praised for its stability