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(101(2)):297-317 doi:10.1016/j.mcna.2016.09.013

Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation

AEs are graded from 1 to 5 according to their severity according to Common Terminology Criteria for Adverse Events
