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Description
Enhancing A3AR signaling with agonists was found to attenuate these adverse effects by reducing neuroinflammation (Doyle et al., 2020)
Crowe J, et al
Kamath, T
The progress was remarkable
During the 7-day treatment schedule, MP-13 maintained stable antinociception without tolerance development, as evidenced by the unchanged microglial cell count in the periaqueductal gray, indicating that chronic exposure did not trigger neuroinflammatory adaptationa process in which microglia become activated, release pro-inflammatory cytokines, and contribute to opioid tolerance
