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The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma Cancer Res 1999 59 : 34953504 Wang TH, Wang HS

De Rosa SC, Zaretsky MD, Dubs JG, et al

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CaMKII activity decays with a time constant of ~10 s, 100 times longer than the Ca 2+ transient, suggesting that CaMKII plays a role in prolonging Ca 2+ initiation signal in the spine

Those are paired with a soothing lineup of Centella asiatica , madecassoside, panthenol, and allantoin to keep skin balanced (as irritation can worsen pigmentation)