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6b), indicated a significant downregulation of genes within the transforming growth factor (TGF) signalling pathway, a main regulator of hepatic fibrosis 51 ( Tgfb1 , Tgfb2 , Tgfbr1 and Tgfbr2 ) as well as key genes related to ECM remodelling ( collagen , type I , -1 ( Col1a1 ), Col1a2 and Col4a1 ) in mice overexpressing AGXT

LDH , lactate dehydrogenase

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Fasano A

The features responsible for the distinct properties of LECs include fenestrations, contractile properties, which propels the fluid through the LVs, and the capability to absorb excess of fluid from the interstitial spaces and transport it back to the bloodstream