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This means you would need much higher doses to achieve similar effects, making these methods less cost-effective and less reliable

Prevalence and perceived health associated with insomnia based on DSM-IV-TR

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Rivera C, Li H, Thomas-Crusells J, Lahtinen H, Viitanen T, Nanobashvili A, Kokaia Z, Airaksinen MS, Voipio J, Kaila K, Saarma M (2002) BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion
