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However, sophisticated adaptive enzymatic mechanisms including superoxide dismutase (SOD), catalase and glutathione peroxidase (GPX), and nonenzymatic antioxidant defence systems such as glutathione (GSH) and vitamins (A, C, E) have evolved to metabolise ROS into less reactive forms to maintain physiological homeostasis and protect cells against oxidant stress [11, 16]

In terms of genetic functions, these genes were predominantly enriched in various neurobiological pathways, including cellular energy metabolism, cytoskeletal organization, protein homeostasis, and synaptic transmission, suggesting intricate mechanisms and comprehensive management of VCI

2012 [cited 2022 Sep 10]

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Ortiz D., Forquer I., Boitz J., Soysa R., Elya C., Fulwiler A., Nilsen A., Polley T., Riscoe M.K., Ullman B., et al

Recent review on selected xenobiotics and their impacts on gut microbiome and metabolome