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Proteasome-independent functions of ubiquitin in endocytosis and signaling

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Morris introduced the task as a way to separate place learning from simple cue approach behavior, and it became the reference assay for spatial memory because the platform can be removed during a probe trial to test memory without reinforcement

Case Example: The High-Functioning, High-Serotonin Anxious Type Patient: 35-year-old female executive History of OCD, social anxiety Racing mind, agitation, gut pain, poor sleep Over-reactive to SSRIs, B vitamins, and magnesium glycinate Genetics: MAOA TT (slow) COMT slow MTHFR + DHFR polymorphisms Treatment: B2 (FAD) and NAC to gently support serotonin clearance Magnesium taurate (instead of glycinate) Antioxidants and anti-inflammatories Niacin + taurine to support neurotransmitter modulation Gut repair and low-histamine, anti-inflammatory diet Results: OCD symptoms diminished within 4 weeks, anxiety dropped significantly, and sleep stabilised without medication