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Description
Gasperl et al., 2021) but after relaxation of stress, oxidized GSSG is reduced back to GSH by GLUTATHIONE REDUCTASE (GR) and NADPH

ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

Also, the upregulation of UCP2 increases the concentration in hypoxia-inducible factor 1-alpha (HIF-1), which reduces PPAR and favors lipid depots

Materials and Methods Chemicals and Reagents 5-Fluorouracil (Cat# F6627), erastin (Cat# E7781) and ferrostatin-1 (Cat# SML0583) were purchased from Sigma-Aldrich (St

27-29 Activated charcoal should only be administered if the patient is mentally alert with an intact airway
