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muciniphila , it has been reported that supplementation with this bacterium increases the number of mucin secreting goblet cells in mice

The M3R is also expressed on brain microvascular endothelium (Radu et al., 2017), and M3R signaling is also important in adaptive immunity and autoimmunity (indeed, M3R is a candidate receptor for autoantigen recognition by T and B cells) (Sumida et al., 2014)

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explicitly pointed out in Nature Reviews Drug Discovery review (120) that maintaining the long-term, stable expression of these complex genetic circuits remains a massive technological chasm

10.1016/j.biopha.2024.116777 Biomed