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In addition, calmangafodipir blocking both the superoxide generation pathway and the hydroxyl generation pathway is likely to contribute to the beneficial therapeutic characteristics of calmangafodipir [157]

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The improvement of DM and its complications by inhibiting ferroptosis in diabetic tissues in drug research is summarized in the table (Table 1)

To investigate the mutational profile of the mutations resulting from each gene deficiency, regression with the full model was repeated on each of the six substitution types as well as on the 96 trinucleotide mutation classes, using the total burden of each mutation type as the response variable