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However, the doses employed in those experiments were much higher than the standard IC 50 for rotenone

For instance, individuals carrying polymorphisms in the deiodinase type 2 gene (DIO2), such as the common Thr92Ala variant, have an altered enzymatic activity and impaired T3 generation at the tissue level, potentially explaining the limited clinical response to LT4 monotherapy in these patients (1416)

Because the structure of non-reduced TrxR1 is too large to calculate using the Quantum chemistry method, a H 2 N-Cys497-Sec498-COO- model containing selenenylsulfide (assigned as R1 in Figure 3A) was used in this calculation

Coagulation abnormalities and thrombosis in patients with COVID-19

Loop regions for both domains I and II are shown in grey