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To elucidate the role of MFAP2 in regulating cholesterol metabolite production within the TME, we first measured 27-HC levels in co-culture supernatants of CT26 colon carcinoma cells and CAFs with stable knockdown of MFAP2

Fuel feeds function: energy metabolism and the T-cell response

doi: 10.3390/cancers13143466

Furthermore, redox-active metals like copper and iron can catalyze the Fenton reaction, generating substantial amounts of ROS, which in turn induces OS and ultimately leads to cell death

The gut microbiota plays a crucial role in shaping these responses, influencing the TME even in distant organs such as the brain