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Dermatoscopic examination revealed a faintly red background with pervasive polygonal vascular networks, pronounced dilatation of numerous pilosebaceous orifices, and minimal areas of orange-yellow discoloration with scant white squamous debris (Figure 2), the VISIA red zone index was 5.08%, affecting a surface area of 1.01% (Figure 4), with CEA, IGA and VAS scores of 1 point each (Table 1)

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Seventy-five patients with type 1 diabetes and various forms of autonomic neuropathy were enrolled in this study: 46 patients (mean age of 38.1 12.5 years) were treated with intravenous ALA (600 mg/day) for 10 days, then with oral ALA (600 mg film tablet/day) for 50 days, while 29 patients (mean age 40.2 9.3 years) served as the untreated control group