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extract lessened the effects of HFD-induced NAFLD rats, possibly by increasing the activity of antioxidant enzyme, inhibiting the MDA in liver and upregulated the expression of LDL-R to regulate the lipid metabolism process ( Naphthalenes can reduce lipid accumulation, liver injury and inflammation, gut microbiota disorders, intestinal barrier injury, and metabolic endotoxemia in HFD induced liver injury ( Oral administration of rhein (150 mg/kg in water) for 40 days significantly increased energy expenditure, reduced body weight, particularly body fat content, improved insulin resistance, and lowered circulating cholesterol levels in DIO mice

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Obesity Reviews (2004) 7