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When NF-kB is active, cells produce tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1 beta (IL-1B), and other proinflammatory cytokines

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Although HLA-DR2 has been identified as a major genetic risk factor for MS its direct association with Cbl deficiency remains uncertain

Of course, there are also some conflicting research results, which require well-designed studies with longer follow-up periods and larger sample sizes for verification