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While there is no clinical support for using lysine supplements to treat the symptoms of shingles, lysine has been found to reduce stress and anxiety, which can lead to decreased immunity, and can help regulate the inflammatory response

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Patten PEM, Buggins AGS, Richards J, Wotherspoon A, Salisbury J, Mufti GJ, et al

Second, lipogenesis decreases, meaning less dietary energy gets converted to stored fat

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