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It can be artificially induced to open by interfering with the BBB through biological, chemical, and physical stimuli

CO 2 concentrations were set at 0, 50, 100, 200, 400, 600, 800, 1000, 1200, 1500 and 2000 mol mol 1 and irradiance levels were set at 1000 mol m 2 s 1 for CO 2 response curve measurements

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Perfluorohexanoic acid caused disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae