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Pendyala, Identification of novel senolytic compounds from natural food sources

Fetal reversion enables villus-derived cells to regenerate tissue without exogenous oncogenic mutations To determine whether the fetal reversion and subsequent conversion to CBCs observed in Alpi+ enterocytes in vitro could also occur under more physiological conditions, we performed primary collagen culture of villus tissues containing tdTomato-labeled Alpi+ cells, followed by in vitro organoid expansion and subsequent transplantation experiments using a DSS-induced colitis model 23,24

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The current FDA and EMA-approved GBCAs are gadobenate (MultiHance), gadobutrol (Gadavist), gadodiamide (Omniscan), gadopentetate (Magnevist), gadoterate (Dotarem), gadoteridol (ProHance), gadoversetamide (OptiMARK), gadoxetate (Eovist), and gadofosveset (Ablavar, US only)

10.1007/s42247-021-00335-x 15 ChengZ.LiM.DeyR.ChenY