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Several factors, including cytokines, proteases, growth factors, gut microbiota, and dietary components are known to regulate intestinal TJs opening ( Intestinal epithelial cells and mononuclear phagocytes sense bacteria or their products mainly through pattern recognition receptors such as TLRs (166)

While these so-called "anti-nutrients" are found in almost all foods, they've gotten a bad rap lately because when consumed in high dosages they can potentially decrease nutrient absorption

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Funct Plant Biol 37:613620