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Laviades C, Mayor G, Diez J

Preclinical acute toxicity is low, with reported rodent LD50 values well above any human-equivalent research dose

Additionally, hyperinsulinemia induces a pro-contractile phenotype in airway smooth muscle (ASM) cells and increases their sensitivity to neural-mediated bronchoconstriction [48,49,50]

Protocol variations between experimental laboratories and inter-species differences in the biological response to antipsychotic drugs have added layers of complexity