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It has attracted significant, sustained attention in in-vitro research focused intensely on connective tissue, skeletal muscle fibers, tendons, ligaments, and highly specialized gastrointestinal tissue models
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Epalrestat is a potent ARI-induced chemosensitivity to doxorubicin and sorafenib through inhibition of AKR1B1 and/or AKR1B10 and blockade of the EMT [145]
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