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doi: 10.1039/C9RA10871H

Radical addition reactions of carotenoids were described for the first time four decades ago (Burton and Ingold 1984)

If your body lacks sufficient B12 due to dietary reasons (e.g., youre vegan and not supplementing) or, more commonly, due to an inability to absorb B12 from your gut (e.g., pernicious anaemia, certain stomach conditions, or medications), then replenishing those levels with an injection will directly address the cause of your fatigue

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It is not a miracle pill, and it will not override severe age-related decline, but the data supporting it is real and replicated