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To delineate tissue-resident macrophages effects on adipocyte development, two days after differentiation 3T3-L1 fibroblasts derived adipocytes were cultured in the presence of conditioned media of BMDM derived from LysM +/+ SerpinB2 fl/fl , LysM cre/+ SerpinB2 fl/fl mice, and NAC-treated LysM cre/+ SerpinB2 fl/fl mice

Figures A2 and A3 summarize the training and inference procedures for the model and the main structure of each component architecture, respectively

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