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In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345

Acyl glucuronides display limited stability, which is dependent on pH, temperature, nature of the aglycon, and so on

Thus, given a large range of comparisons of different methods of drug administration in one model, along with the used animal models, the obtained results could be regarded as very reliable

However, critical knowledge gaps persist in translating these findings to elderly populations: (1) Existing studies predominantly rely on animal models or young/middle-aged cohorts, with minimal data on long-term efficacy and safety in frail older adults (75 years) exhibiting multimorbidity or polypharmacy

New York, NY, USA: 2018