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A recent comprehensive in vivo study performed in fully awake mice provides evidence that astrocyte Ca 2+ does not initiate or mediate neurovascular coupling when neuronal activation is short ( 40 kDa) but not small ( 50%) seems to be required to induce BBB leakage (101)
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Deleted mtDNA in patients cells exists in varying proportions relative to normal mtDNA, a mixture termed heteroplasmy
