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Leveraging its amphiphilic biochemical property [94], melatonin not only traverses the BBB but also gains access to brain cells and brain cell organelles, including mitochondria

363 Interestingly, in aging tissues, the inhibition of key molecules with high activity in oxidative stress and strong ROS inducers, such as p38, can restore the function of HSCs

View Abstract Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells

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Thus, the ascorbate-glutathione pathway was assigned a key function in the metabolism of hydrogen peroxide in the chloroplasts (Foyer and Halliwell, 1976) while glutathione became implicated in stress resistance in general (Esterbauer and Grill, 1978
