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Figure 1 Iron metabolism At present, the exact molecular mechanism of iron overload leading to heart damage is mainly considered to be ferroptosis ( 2+ uniporter, which is essential in causing mitochondrial dysfunction and ferroptosis in cardiac iron overload ( Hepcidin, a peptide hormone originated from the liver, regulates iron absorption and distribution by suppressing the activity of transferrin (57)

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Unlike existing MS/MS spectrum predicting tools, such as NEIMS and CFM-ID 4.0, that are generic for all molecules, DeepCDM aims to enhance the spectrum predictability of a more focused group of molecules undergone given chemical derivatizations

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