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In particular, we ask whether pharmacological manipulations that either reverse or exacerbate the redox changes observed in Cdk5-KO are beneficial or detrimental to the survival of these mutant flies

Table S9

PMID: 21435090

In contrast, the 3R-MYB and 4R-MYB families are much smaller, with only a few members in some species [496]

Current evidence indicates that ROS are major mediators of tissue injury in MS, promoting OS that disrupts the structural and functional integrity of lipids, proteins, and nucleic acids ( Under pathological conditions, OS-induced disruption of the BBB facilitates the infiltration of inflammatory cells into the CNS, where they release cytokines and other mediators that amplify neuroinflammation, creating a self-perpetuating pathological cycle