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Similarly, combined therapy of sildenafil and OSU-03012 improved the efficacy of the therapy in glioblastoma cells by decreasing the expression of plasma membrane receptors and drug efflux pumps (143)

Ravandi F, Kantarjian H, Cortes J, Thomas D, Faderl S, Jones D, Jabbour E, Koller C, Dara S, Garris R, Kebriaei P, Borthakur G , Ferrajoli A, O'Brien S

In contrast, the Rap1 signaling pathway was significantly activated in the EGCG-Zn-treated group

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