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when additional pharmacotherapy is needed, selection should be guided by liver disease severity, pain type and comorbidity profile, with close monitoring for adverse effects
[19] These licensed treatments offer a far safer, evidence-based alternative to unlicensed investigational compounds
Radiology 258 , 174181 (2011)
However, ATP consumption is also lower ( Figure 4C ) due to the lower levels of Na + /K + -ATPase (40, 41), and therefore ATP supply is not necessarily a limiting factor
