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Associations between metabolites in the aqueous humor of glaucoma patients and with clinical parameters We analyzed the associations between the identified metabolites with Spearmans rank correlation coefficient analysis

Trends Genet 13:335340 Bernstein BE, Meissner A, Lander ES (2007) The mammalian epigenome

Cognitive Enhancement Studies Cognitive improvement studies in 28-month-old mice (equivalent to elderly humans) using 10 mg/kg body weight administered 5x per week for 3 weeks demonstrated: Significantly faster escape hole finding in Box Maze tests (trials 4 and 5) Evidence of decreased brain inflammation Increased histone deacetylase 2 labeling indicating epigenetic pathway activation Preliminary reversal of age-related cognitive impairment Pain and Anxiety Modulation Anti-pain effects in mice at 0.5 mg/kg showed efficacy comparable to cimetidines human analgesic effects, affecting 7 anti-pain genes (increased) and 2 genes (decreased), with upregulated opioid receptors and related pain-modulating pathways

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The PINK1/Parkin pathway is a central mechanism for removing senescent or irreversibly damaged mitochondria