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Clinical trials evaluating metformin in combination with chemotherapy, targeted therapy, or immunotherapy in NSCLC are ongoing with mixed results

CKL8 stabilizes the core clock negative arm by reducing the levels of PER2 in the TTFL positive arm and enhances the magnitude of circadian rhythm in cells

Data availability The raw data of RNA-sequencing reported in this study has been deposited in the public database of Genome Sequence Archive (GSA) in National Genomics Data Center under the accession number HRA002453, which is accessible at The untargeted metabolomics data was included in an Excel form which is named as untargeted metabolomic data in the Source Data file

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10.1590/S0037-86822012000600010 Rev