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The therapeutic potential of glyoxalase inhibitors for the treatment of SCLC was previously reported 6 , and we attempted to discover novel glyoxalase inhibitors via the live cell-based HTS using SCLC cells

Second, the cross-sectional nature of the study limits our ability to establish causality and exclude the potential reverse causation between biomarkers and diseases, highlighting the need for larger interventional studies

(PubMed) Raiskup F, Spoerl E

ACSL4 is generally upregulated in OA cartilage tissue, and its continuous activation expands the pool of oxidizable lipid substrates, thereby significantly increasing the tendency for ferroptosis (Guan et al., 2025

In Vitro Assays Because studies in humans and animals are expensive, time-consuming, sometimes ethically questionable, and often difficult to interpret, researchers have developed a number of in vitro laboratory studies to investigate the effects of free radicals and oxidative stress on cells