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Biomarkers of oxidative stress are significantly elevated in Down syndrome

Interestingly, there is a poor correlation between RNA expression changes after T cell activation and the levels of encoded proteins, suggesting that regulation of much of the proteome in these cells occurs posttranscriptionally (37, 39)

Given the hypothesis proposed regarding reduced glutathione biosynthesis around this timeframe within our study, conversion of excess GLY to other amino acids offers a plausible explanation

More and more research reveals that neurovascular disorders play an important role in the pathophysiology of brain diseases throughout life, such as neurodevelopmental and neurodegenerative disorders (Ouellette et al