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378 Furthermore, the ArtemiC oral spray (artemisinin 6 mg/mL, curcumin 20 mg/mL, frankincense 15 mg/mL, and vitamin C 60 mg/mL) given twice a day on day 1 and 2 of a double-blind multicenter phase II clinical trial showed remarkable clinical improvement, including reduced O 2 supplementation duration, fever duration, hospital admission time, and abnormal oxygen saturation (SpO 2 ) duration in patients with COVID-19 ( n = 33), compared to those who received a placebo ( n = 17)

Reduced GSH and oxidized GSSG are well-known substrates of MRP-1 and are transported or undergo co-efflux in various physiological processes and pharmacological conditions 3

R.BalasubramanianP.et al

There are two types of inhibition of P450 enzymes: reversible and irreversible, the latter of which is also known as mechanism-based inhibition (Pelkonen et al., 2008)

Primers and plasmid lists are provided in the Supplementary Information