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No other single peptide addresses the ECM this comprehensively

Mechanical and chemical stimulation of the gut by the passage of a bolus, pressure due to distension or microbial mediators, nutrients, toxins, or irritants activates the mechano- and/or chemosensory systems of the intestinal epithelium to initiate digestive and defensive reflexes (409, 413, 423426)

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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

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