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Subsequent cholesterol transport is mediated by ApoE, but it seems less important than the 24-OHC-mediated mechanism (Leon et al., 2005)

Results Results were visible in several brain areas, including the substantia nigra of the midbrain and the medial anterior olfactory nucleus, with a simultaneous decrease in the hypothalamus, ventral and dorsal hippocampus, and dorsal thalamus

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This explains the universal unspecific toxicity of the HO radical towards any chemical structure at the site of its generation against which no protection whatsoever is possible