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ES2 preferentially binds and eliminates FOXO4+ cells in a wide range of cell types Based on our initial screening, we chose to characterize ES2 at greater depth

However, in patients with PD, factors such as glutathione (GSH) depletion, impaired function of the Nrf2/ARE signaling pathway, and mitochondrial dysfunction contribute to a significant decrease in antioxidant levels in the substantia nigra region

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Abdalla et al., Inhaled mRNA nanoformulation with biogenic ribosomal protein reverses established pulmonary fibrosis in a bleomycin-induced murine model

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