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Graves Disease Most of the earliest research (starting in 1959, through early 2000) relating to carnitine and thyroid disease was actually focused on Graves disease

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2.3 Diagnosis and management Peripheral fatigue can be quantified through objective assessments of strength and aerobic capacity, while central fatigue is evaluated using self-reports and validated questionnaires that capture the patients perception of physical and mental exertion impacts on their activities and exertion levels

& Bauer, F