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& Farese, R

Decreased activity of the mitochondrial respiratory chain was reported in overweight/obese patients with NASH compared to controls [97, 98], and alterations in mitochondrial ultrastructure have been observed prior to NAFLD development in the Otsuka LongEvans Tokushima Fatty rat [99] as well as in patients with steatosis preceding progression to NASH [100]

M.KahnC
Konopleva M, Zhao S, Jiang S, Snell V, Andreeff M

MSH deficiency also causes early phase obesity and increases food intake and body weight [9]
